Acid reflux study of decomposition of melamine causes kidney damage and repair
Recently, the Harbin University of Commerce life sciences and Environmental Sciences Research Center researchers published papers, aims to analyse the animals melamine-cyanuric acid after exposure sources and renal lesions in the repair process. Research indicates that between in vitro experiments show that melamine and cyanuric acid in the presence of gastric acid decomposition can be pure chemical reactions; stop melamine after exposure in vivo experiments showed that rats, kidney damage can gradually repair itself. This paper was published in 2015 No. 05 issue of the journal of toxicology.
800 ng/ml of melamine solution regulation p h value respectively for 3, and 4, and 5 and 6 h Hou put placed 37 ℃ of thermostat waters pot within acidification to simulation stomach Department conditions, respectively set reaction time for 1, and 2 and 3 h Hou, 70 ℃ nitrogen blow dry Hou with gas phase color spectrum-quality spectrum method detection reaction end liquid in the by containing melamine and three poly Cyanate concentration. 78 Wistar male rats were randomly divided into control and experimental groups, 60 in the experimental group and the control group 18. Experimental animals exposed to doses of 25 mg/kg, Chan into feed infected 5 weeks. In exposure, respectively 2, 3, and 5 weeks, and 2 weeks after the exposure stops, 6 weeks and 12 weeks 10 animals in the experimental group and the control group 3 renal function and renal Histopathological examination.
Results show melamine in vitro under simulated stomach acid may decompose into cyanuric acid, and decomposition with p h is a linear relationship between value and time. In rats treated with melamine after 5 weeks of BUN and CRE significantly higher animals, and pathology has changed significantly. But after the cessation of exposure without any intervention, animal kidney damage can gradually recover by itself.